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Eculizumab

CAT: 0804-HY-P9914-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P9914-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC) . Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies[1][2].
CAS Number
219685-50-4
Product Name Alternative
Anti-Human C5, Humanized Antibody; h5G1.1
UNSPSC
12352203
Target
Complement System
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/eculizumab.html
Purity
99.88
Solubility
H2O
Smiles
[Eculizumab]
Molecular Weight
(145.74 kDa)
References & Citations
[1]Eline A Dubois, et al. Eculizumab. Br J Clin Pharmacol. 2009 Sep;68 (3) :318-9.|[2]Halstead SK, et al. Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model. Brain. 2008 May;131 (Pt 5) :1197-208.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

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