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Fast Green FCF

CAT: 0804-HY-D0914-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0914-01Size:500 mg
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Description
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function[1][2][3][4][5][6][7][8][9].
CAS Number
2353-45-9
Product Name Alternative
FD&C Green No. 3; Food green 3; C.I. 42053
UNSPSC
12171500
Hazard Statement
H335, H341
Target
α-synuclein
Type
Dye Reagents
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Fast-Green-FCF.html
Concentration
10mM
Purity
99.95
Solubility
H2O : 10 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(C/[N+](CC)=C2C=C/C(C=C/2)=C(C3=CC=C(N(CC)CC4=CC=CC(S(=O)(O[Na])=O)=C4)C=C3)\C5=CC=C(O)C=C5S(=O)(O[Na])=O)=CC=C1)([O-])=O
Molecular Formula
C37H34N2Na2O10S3
Molecular Weight
808.85
Precautions
H335, H341
References & Citations
[1]Mittal A, et al. Batch and bulk removal of a triarylmethane dye, Fast Green FCF, from wastewater by adsorption over waste materials. J Hazard Mater. 2009 Apr 30;163 (2-3) :568-77. |[2]How SC, et al. Examining the inhibitory potency of food additive fast green FCF against amyloid fibrillogenesis under acidic conditions. Food Funct. 2016 Dec 7;7 (12) :4898-4907.|[3]van Hooft JA. Fast Green FCF (Food Green 3) inhibits synaptic activity in rat hippocampal interneurons. Neurosci Lett. 2002 Feb 1;318 (3) :163-5.|[4]Wang F, et al. The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity. Food Funct. 2021 Jun 21;12 (12) :5465-5477.|[5]Liu F, et al. Fast green FCF inhibits Aβ fibrillogenesis, disintegrates mature fibrils, reduces the cytotoxicity, and attenuates Aβ-induced cognitive impairment in mice. Int J Biol Macromol. 2021 Feb 15;170:33-41.|[6]Liu J, et al. Fast green FCF prevents postoperative cognitive dysfunction via the downregulation of the P2X4 receptor in mice. Int Immunopharmacol. 2023 Aug;121:110462.|[7]Yang J, et al. Fast Green FCF Attenuates Lipopolysaccharide-Induced Depressive-Like Behavior and Downregulates TLR4/Myd88/NF-κB Signal Pathway in the Mouse Hippocampus. Front Pharmacol. 2019 May 8;10:501.|[8]Xu F, et al. Fast Green FCF Alleviates Pain Hypersensitivity and Down-Regulates the Levels of Spinal P2X4 Expression and Pro-inflammatory Cytokines in a Rodent Inflammatory Pain Model. Front Pharmacol. 2018 May 23;9:534.|[9]Dixit A, et al. ASSESSMENT OF REPRODUCTIVE TOXICITY CAUSED BY FAST GREEN FCF ON MALE SWISS ALBINO MICE. 2012.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

Chemical Information

Fast Green FCF

Fast green FCF is an organic sodium salt having 2-{(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}-5-hydroxybenzene-1-sulfonate as the counterion. Used as a substitute for Light green SF yellowish in Masson's trichrome as it is less likely to fade, and is more brilliant in colour. Also used as a food colouring agent. It has a role as a fluorochrome, a histological dye and a food colouring. It contains a Fast green FCF(2-).

CAS Number2353-45-9
PubChem CID16887
IUPAC Namedisodium;2-[[4-[ethyl-[(3-sulfonatophenyl)methyl]amino]phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]-5-hydroxybenzenesulfonate
Molecular FormulaC37H34N2Na2O10S3
Molecular Weight808.9
Topological Polar Surface Area223
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Heavy Atom Count54
Formal Charge0
Complexity1540
SMILES
CCN(CC1=CC(=CC=C1)S(=O)(=O)[O-])C2=CC=C(C=C2)C(=C3C=CC(=[N+](CC)CC4=CC(=CC=C4)S(=O)(=O)[O-])C=C3)C5=C(C=C(C=C5)O)S(=O)(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C37H36N2O10S3.2Na/c1-3-38(24-26-7-5-9-33(21-26)50(41,42)43)30-15-11-28(12-16-30)37(35-20-19-32(40)23-36(35)52(47,48)49)29-13-17-31(18-14-29)39(4-2)25-27-8-6-10-34(22-27)51(44,45)46;;/h5-23H,3-4,24-25H2,1-2H3,(H3,41,42,43,44,45,46,47,48,49);;/q;2*+1/p-2
InChIKey
RZSYLLSAWYUBPE-UHFFFAOYSA-L
Chemical Structure
2D Structure
2D structure of Fast Green FCF
CAS: 2353-45-9
CID: 16887
Formula: C37H34N2Na2O10S3
MW: 808.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight808.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass808.11709737
Monoisotopic Mass808.11709737
Topological Polar Surface Area223 Ų
Heavy Atom Count54
Formal Charge0
Complexity1540
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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