Curcumin-β-D-glucuronide

• Description:

  Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/curcumin-β-d-glucuronide.html

• Purity:

  98.01

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  COC (C=C (C=C1) /C=C/C (CC (/C=C/C2=CC (OC) =C (C=C2) O) =O) =O) =C1O[C@@H]3O[C@@H] ([C@H] ([C@@H] ([C@H]3O) O) O) C (O) =O

• Molecular Formula:

  C27H28O12

• Molecular Weight:

  544.50

• Precautions:

  H302+H312+H332, H315, H319, H335

• References & Citations:

  [1]Ozawa-Umeta H, et, al. Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. Cancer Sci. 2020 May;111 (5) :1785-1793.|[2]Ozawa H, et, al. Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood. Biol Pharm Bull. 2017;40 (9) :1515-1524.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  227466-72-0