Curcumin-β-D-glucuronide

• Description :

  Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302+H312+H332, H315, H319, H335

• Target :

  Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/curcumin-β-d-glucuronide.html

• Purity :

  98.01

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)O)=O)=O)=C1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O

• Molecular Formula :

  C27H28O12

• Molecular Weight :

  544.50

• Precautions :

  H302+H312+H332, H315, H319, H335

• References & Citations :

  [1]Ozawa-Umeta H, et, al. Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. Cancer Sci. 2020 May;111 (5) :1785-1793.|[2]Ozawa H, et, al. Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood. Biol Pharm Bull. 2017;40 (9) :1515-1524.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [227466-72-0]