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CZC24832

CAT: 0804-HY-15294-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15294-01Size:5 mg
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Description
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kdapp) of 19 nM.
CAS Number
1159824-67-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/CZC24832.html
Purity
99.07
Solubility
DMSO : ≥ 53 mg/mL
Smiles
FC1=CC(C2=CC(S(=O)(NC(C)(C)C)=O)=CN=C2)=CN3C1=NC(N)=N3
Molecular Formula
C15H17FN6O2S
Molecular Weight
364.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Bergamini G, et al. A selective inhibitor reveals PI3Kγ dependence of T (H) 17 cell differentiation. Nat Chem Biol. 2012 Apr 29;8 (6) :576-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kβ; PI3Kγ; PI3Kδ

Chemical Information

Czc-24832
CAS Number1159824-67-5
PubChem CID42623951
IUPAC Name5-(2-amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide
Molecular FormulaC15H17FN6O2S
Molecular Weight364.4
XLogP1
Topological Polar Surface Area124
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity578
SMILES
CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)F
InChI
InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-9(6-18-7-11)10-5-12(16)13-19-14(17)20-22(13)8-10/h4-8,21H,1-3H3,(H2,17,20)
InChIKey
RXRZPHQBTHQXSV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Czc-24832
CAS: 1159824-67-5
CID: 42623951
Formula: C15H17FN6O2S
MW: 364.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.4
XLogP31
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass364.11177314
Monoisotopic Mass364.11177314
Topological Polar Surface Area124 Ų
Heavy Atom Count25
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1676-25CZC24832
A11363-100CZC24832 100mg
A11363-50CZC24832 50mg
A11363-2CZC24832 2mg
A11363-1CZC24832 1mg
A11363-25CZC24832 25mg
A11363-10CZC24832 10mg
A11363-5CZC24832 5mg

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