Products for Research Use Only
RegisterLogin

LAR Antibody, Clone N165/38: FITC

CAT: 0400-SMC-443D-FITCSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0400-SMC-443D-FITCSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
LAR (Leukocyte Common Antigen-Related Protein), encoded by PTPRF, is a receptor-type protein tyrosine phosphatase involved in neural development and regeneration. It regulates cell adhesion, cytoskeletal dynamics, and synaptic plasticity by dephosphorylating β-catenin and modulating cadherin-mediated junctions. LAR influences neurite outgrowth, axon guidance, and actin remodeling, making it critical for neurodevelopment and repair. In neurodegenerative contexts, LAR dysregulation may impair synaptic stability and neuronal connectivity. Its role in insulin signaling and inflammation further links it to metabolic and neurodegenerative disorders. As a modulator of synaptic architecture and signaling, LAR represents a potential target for therapeutic strategies aimed at restoring neural function.
Description
Mouse Anti-Human LAR (PTPRF) Monoclonal IgG2a
CAS Number
9007-83-4
Specifications
Detects ~85kDa (full length protein is 210 kDa – smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains.
Product Name Alternative
PTPRF, LAR, Leukocyte antigen related, Leukocyte antigen related PTP receptor, Leukocyte antigen related tyrosine phosphatase, Leukocyte common antigen related, Receptor-type tyrosine-protein phosphatase F, Receptor type tyrosine protein phosphatase F precursor, Protein Tyrosine Phosphatase Receptor Type F, Protein tyrosine phosphatase receptor type F polypeptide, Receptor linked phosphatase LAR, LAR protein, LARS, LARFN5C, LCA homolog, FLJ43335, FLJ45062, FLJ45567
Synonyms
LAR/PTPRF Antibody, Clone N165/38: FITC
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
5792
Swiss Prot
P10586
Accession Number
NP_002831.2.
Cellular Locus
Membrane
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR. 97% identical in both rat and mouse. >80% identity with PTPRD and PTPRS. >50% identity with PTPRM and PTPRK.
Target
LAR
Clonality
Monoclonal
Isotype
IgG2a
Clone
N165/38 (Formerly sold as S165-38)
Conjugation
FITC
Type
Monoclonal
Applications
WB | ICC/IF
Validated Applications
IHC, ICC/IF
Field of Research
Cell Signaling | Post-translational Modifications | Phosphorylation | Neuroscience | Cell Markers
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-443 was sufficient for detection of LAR/PTPRF in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Streuli M. M., et al. (1992) EMBO Journal, 11(3), 897-907. 2. Mooney R.A. and C.M LeVea. (2003) Current Topics in Medicinal Chemistry, 3(7), 809-819. 3. Chagnon M.J., et al. (2004) Biochemistry and Cell Biology, 82(6), 664-675. 4. Ahmad F.F., and B.J. Goldstein (1997) Journal of Biological Chemistry, 272(1), 448-457.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
Conjugated antibodies should be stored according to the product label
Specificity
Detects ~85kDa (full length protein is 210 kDa – smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains.
Background Reference 01
1. Streuli M. M., et al. (1992) EMBO Journal, 11 (3), 897-907. 2. Mooney R.A. and C.M LeVea. (2003) Current Topics in Medicinal Chemistry, 3 (7), 809-819. 3. Chagnon M.J., et al. (2004) Biochemistry and Cell Biology, 82 (6), 664-675. 4. Ahmad F.F., and B.J. Goldstein (1997) Journal of Biological Chemistry, 272 (1), 448-457.
Species
Human | Mouse | Rat
Location
Membrane
Isotype
IgG2a
Immunogen Species
Human

Related Products

CatalogName
SMC-443DLAR Antibody, Clone N165/38
SMC-443SLAR Antibody, Clone N165/38
SMC-443D-HRPLAR Antibody, Clone N165/38: HRP
SMC-443D-PCPLAR Antibody, Clone N165/38: PerCP
SMC-443D-RPELAR Antibody, Clone N165/38: RPE
SMC-443D-APCLAR Antibody, Clone N165/38: APC
SMC-443D-BILAR Antibody, Clone N165/38: Biotin
SMC-443D-A488LAR Antibody, Clone N165/38: ATTO 488
SMC-443D-A390LAR Antibody, Clone N165/38: ATTO 390
SMC-443D-A594LAR Antibody, Clone N165/38: ATTO 594

Alternative Products

CatalogName
73-193LAR (PTPRF) mouse monoclonal antibody, clone N165/38
75-193LAR (PTPRF) Mouse Monoclonal Antibody [Clone ID: N165/38]
73-194LAR (PTPRF) mouse monoclonal antibody, clone N165/43
99-341CD11a Antibody [38] (FITC)
75-194LAR (PTPRF) Mouse Monoclonal Antibody [Clone ID: N165/43]
AMM01712GMonoclonal COPS5 / JAB1 Antibody (clone 6C3.38), Clone: 6C3.38
36-11032-100Monoclonal Antibody to Clone : IPO-38 (Proliferation Marker) (Clone : IPO-38)
MBS520793-01Anti-Human CD11a, FITC, (clone: 38) (Mouse IgG2a)
AMM06261GMonoclonal LGALS3 / Galectin 3 Antibody (clone M3/38), Clone: M3/38
FGN55611Anti-CD77 Antibody (38.13), FITC

Popular Products