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DC-Chol (hydrochloride)

CAT: 0804-HY-137131-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137131-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity[1][2][3].
CAS Number
166023-21-8
Product Name Alternative
DC-Cholesterol (hydrochloride)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; IFNAR; Interleukin Related; Liposome
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dc-chol-hydrochloride.html
Purity
99.91
Solubility
Ethanol : 12.5 mg/mL (ultrasonic)
Smiles
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCN(C)C)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C.[H]Cl
Molecular Formula
C32H57ClN2O2
Molecular Weight
537.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120 (1) :59-68.|[2]Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111 (5) :e23343.|[3]Brunel F, et al. Cationic lipid DC-Chol induces an improved and balanced immunity able to overcome the unresponsiveness to the hepatitis B vaccine. Vaccine. 1999 Apr 23;17 (17) :2192-203.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 1

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