Products for Research Use Only
RegisterLogin

Sirukumab

CAT: 0804-HY-P99316-01Size: 1 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P99316-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis[1][2].
CAS Number
1194585-53-9
Product Name Alternative
CNTO-136
UNSPSC
12352203
Target
Interleukin Related
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sirukumab.html
Purity
96.83
Solubility
10 mM in DMSO
Smiles
[Sirukumab]
Molecular Weight
(144.58 kDa)
References & Citations
[1]Brad H Rovin, et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Treatment With Sirukumab (CNTO 136) in Patients With Active Lupus Nephritis. Arthritis Rheumatol. 2016 Sep;68 (9) :2174-83.|[2]Bartoli F, et al. Sirukumab for the treatment of rheumatoid arthritis: update on sirukumab, 2018[J]. Expert Review of Clinical Immunology, 2018, 14 (7) : 539-547.|[3]Gardner D, et al. THU0042 Preclinical Characterization of Sirukumab, a Human Monoclonal Antibody that Targets Human Interleukin-6 Signaling[J]. Annals of the Rheumatic Diseases, 2015, 74: 207.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

Alternative Products

CatalogName
T76826-01Sirukumab
592201Sirukumab (IL6)
GTR18337954-01Sirukumab Antibody
DY328038Sirukumab ELISA Kit
E55B0248Sirukumab (Reference antibody)
DHC15803Research Grade Sirukumab
KBI1636KRIBIOLISA™ Sirukumab ELISA
A138194Sirukumab Biosimilar (Monoclonal, IgG1)
ICH5869-1mgSirukumab Biosimilar - Research Grade
GTR18780403-01(Sirukumab) Biosimilar Reference Antibody

Popular Products