Z-VA-DL-D-FMK

• UNSPSC Description:

  Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) is an inhibitor for caspase[1]. Z-VA-DL-D-FMK binds irreversibly to caspases, increases the sensitivity of TNF-α, and activates HIV replication in infected T cell ACH-2[1].

• Target Antigen:

  Caspase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/z-va-dl-d-fmk.html

• Smiles:

  O=C(CF)C(NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC(O)=O

• Molecular Weight:

  453.46

• References & Citations:

  [1]Scheller C, et al., Caspase inhibition activates HIV in latently infected cells. Role of tumor necrosis factor receptor 1 and CD95. J Biol Chem. 2002 May 3;277(18):15459-64.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  220644-02-0