Products for Research Use Only
RegisterLogin

VHL Polyclonal Antibody

CAT: 0749-ABP60891-01Size: 30 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0749-ABP60891-01Size:30 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL is the basis of familial inheritance of VHL syndrome. The protein encoded by VHL is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Description
Rabbit Anti-VHL Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL
Gene ID
7428
Accession Number
P40337
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human VHL protein at amino acid sequence of 1-50
Clonality
Polyclonal
Tag
VHL
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
19-24kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of VHL
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200
Other Product Names
Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P40337
Isotype
Rabbit IgG

Related Products

CatalogName
ABP56499-01VHL (phospho Ser68) Polyclonal Antibody
PPT-16003Human VHL Recombinant Protein
ANT-13843-100ugPolyclonal Antibody
ANT-13843-50ugPolyclonal Antibody
ANT-15047-100ugWAS Polyclonal Antibody
ANT-15047-50ugWAS Polyclonal Antibody
ABP51603-01IKKBeta Polyclonal AntibodyIKKβ Polyclonal Antibody
ABP50715-01AR-Beta2 Polyclonal AntibodyAR-β2 Polyclonal Antibody
ABP51469-01GPR83 Polyclonal Antibody
ABP60870-01VANG2 Polyclonal Antibody

Alternative Products

CatalogName
APR00460GPolyclonal Spt16 polyclonal antibody
APG01659GPolyclonal AKR1B10 Polyclonal Antibody
APR11188GPolyclonal Rtf1 polyclonal antibody
AMR09486GPolyclonal PPARG polyclonal antibody
APR13475GPolyclonal SOX4 polyclonal antibody
APR00375GPolyclonal JMJD2c polyclonal antibody
APR00449GPolyclonal Hira polyclonal antibody
APR12525GPolyclonal MeCP2 polyclonal antibody
APR00376GPolyclonal BMI1 polyclonal antibody
APR00459GPolyclonal CHD4 polyclonal antibody

Popular Products