TIPRL Polyclonal Antibody

• Background :

  TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene. May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A) . Isoform 1 inhibits catalytic activity of the PP2A (D) core complex in vitro. The PP2A (C) : TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C: pPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX) . May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

• Description :

  Rabbit Anti-TIPRL Polyclonal Antibody

• Product Name Alternative :

  TIP41-like protein; Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP

• Gene ID :

  261726

• Accession Number :

  O75663

• Reactivity :

  Human, Rat, Mouse

• Immunogen :

  Synthesized peptide derived from part region of human TIPRL protein

• Clonality :

  Polyclonal

• Tag :

  TIPRL

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  29kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of TIPRL protein

• Observed Molecular Weight :

  29

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names :

  TIP41-like protein; Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/O75663

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG