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TIPRL Polyclonal Antibody

CAT: 0749-ABP60695-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP60695-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene. May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A) . Isoform 1 inhibits catalytic activity of the PP2A (D) core complex in vitro. The PP2A (C) : TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C: pPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX) . May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Description
Rabbit Anti-TIPRL Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
TIP41-like protein; Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP
Gene ID
261726
Accession Number
O75663
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human TIPRL protein
Clonality
Polyclonal
Tag
TIPRL
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
29kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of TIPRL protein
Observed Molecular Weight
29
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
TIP41-like protein; Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O75663
Isotype
Rabbit IgG

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