RO52 Polyclonal Antibody

CAT: 0749-ABP60223-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP60223-01Size:30 µL
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Background
TRIM21 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for TRIM21 have been described but the full-length nature of only one has been determined.
Description
Rabbit Anti-RO52 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
E3 ubiquitin-protein ligase TRIM21 ;52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro (SS-A) ; Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21
Gene ID
6737
Accession Number
P19474
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human RO52 protein at amino acid sequence of 140-220
Clonality
Polyclonal
Tag
RO52
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
52kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of RO52 protein
Observed Molecular Weight
52
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
E3 ubiquitin-protein ligase TRIM21 ;52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro (SS-A) ; Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P19474
Isotype
Rabbit IgG

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