PTPRM Polyclonal Antibody

CAT: 0749-ABP60041-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP60041-01Size:30 µL
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Background
Protein Tyrosine Phosphatase, Receptor Type M encoded by PTPRM is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
Description
Rabbit Anti-PTPRM Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Receptor-type tyrosine-protein phosphatase mu; Protein-tyrosine phosphatase mu; R-PTP-mu
Gene ID
5797
Accession Number
P28827
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human PTPRM protein
Clonality
Polyclonal
Tag
PTPRM
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
159kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of PTPRM protein
Observed Molecular Weight
159
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Receptor-type tyrosine-protein phosphatase mu; Protein-tyrosine phosphatase mu; R-PTP-mu
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P28827
Isotype
Rabbit IgG

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