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PTPRK Polyclonal Antibody

CAT: 0749-ABP60040-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP60040-01Size:30 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by PTPRK is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRK possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. PTPRK was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of PTPRK was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
Description
Rabbit Anti-PTPRK Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Receptor-type tyrosine-protein phosphatase kappa; Protein-tyrosine phosphatase kappa; R-PTP-kappa
Gene ID
5796
Accession Number
Q15262
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human PTPRK protein at amino acid sequence of 180-260
Clonality
Polyclonal
Tag
PTPRK
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
158kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of PTPRK protein
Observed Molecular Weight
158
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Receptor-type tyrosine-protein phosphatase kappa; Protein-tyrosine phosphatase kappa; R-PTP-kappa
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q15262
Isotype
Rabbit IgG

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