PSPC1 Polyclonal Antibody

• Background:

  PSPC1 (Paraspeckle Component 1) is a Protein Coding gene. Diseases associated with PSPC1 include Eec Syndrome and Rapp-Hodgkin Syndrome. Among its related pathways are Circadian rythm related genes. PSPC1 encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by PSPC1 is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of PSPC1 results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.

• Description:

  Rabbit Anti-PSPC1 Polyclonal Antibody

• Product Name Alternative:

  Paraspeckle component 1; Paraspeckle protein 1

• Gene ID:

  55269

• Accession Number:

  Q8WXF1

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Synthesized peptide derived from part region of human PSPC1 protein at amino acid sequence of 10-90

• Clonality:

  Polyclonal

• Tag:

  PSPC1

• Applications:

  WB, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  57kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  The antibody detects endogenous levels of PSPC1 protein

• Observed Molecular Weight:

  57

• Formulation:

  Liquid solution

• Buffer pH:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names:

  Paraspeckle component 1; Paraspeckle protein 1

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/Q8WXF1

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG