PDE3A Polyclonal Antibody

• Background :

  PDE3A encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PDE3A.

• Description :

  Rabbit Anti-PDE3A Polyclonal Antibody

• Product Name Alternative :

  CGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A

• Gene ID :

  5139

• Accession Number :

  Q14432

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthesized peptide derived from part region of human PDE3A protein at amino acid sequence of 250-330

• Clonality :

  Polyclonal

• Tag :

  PDE3A

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  125kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of PDE3A protein

• Observed Molecular Weight :

  125

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names :

  CGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q14432

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG