PDE3A Polyclonal Antibody

CAT: 0749-ABP59862-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP59862-01Size:30 µL
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Background
PDE3A encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PDE3A.
Description
Rabbit Anti-PDE3A Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A
Gene ID
5139
Accession Number
Q14432
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human PDE3A protein at amino acid sequence of 250-330
Clonality
Polyclonal
Tag
PDE3A
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
125kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of PDE3A protein
Observed Molecular Weight
125
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
CGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q14432
Isotype
Rabbit IgG

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