Products for Research Use Only

PCM1 Polyclonal Antibody

CAT: 0749-ABP59847-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP59847-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PCM1 (Pericentriolar Material 1) is a Protein Coding gene. Diseases associated with PCM1 include Differentiated Thyroid Carcinoma and Atypical Chronic Myeloid Leukemia. Among its related pathways are DNA Damage and Regulation of PLK1 Activity at G2/M Transition. The protein encoded by PCM1 is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for PCM1.
Description
Rabbit Anti-PCM1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Pericentriolar material 1 protein; PCM-1; hPCM-1
Gene ID
5108
Accession Number
Q15154
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human PCM1 protein at amino acid sequence of 140-220
Clonality
Polyclonal
Tag
PCM1
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
222kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of PCM1 protein
Observed Molecular Weight
222
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Pericentriolar material 1 protein; PCM-1; hPCM-1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q15154
Isotype
Rabbit IgG