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ITFG2 Polyclonal Antibody

CAT: 0749-ABP58981-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58981-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with ITFG2 include Distal Arthrogryposis. As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Description
Rabbit Anti-ITFG2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
KICSTOR complex protein ITFG2; Integrin-alpha FG-GAP repeat-containing protein 2
Gene ID
55846
Accession Number
Q969R8
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human ITFG2 protein at amino acid sequence of 40-120
Clonality
Polyclonal
Tag
ITFG2
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
49kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of ITFG2 protein
Observed Molecular Weight
49
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
KICSTOR complex protein ITFG2; Integrin-alpha FG-GAP repeat-containing protein 2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q969R8
Isotype
Rabbit IgG

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