INVS Polyclonal Antibody

• Background:

  INVS (Inversin) is a Protein Coding gene. Diseases associated with INVS include Nephronophthisis 2, Infantile and Nephronophthisis 16. Among its related pathways are Wnt Signaling Pathway and Pluripotency. INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in INVS have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for INVS.

• Description:

  Rabbit Anti-INVS Polyclonal Antibody

• Product Name Alternative:

  Inversin; Inversion of embryo turning homolog; Nephrocystin-2

• Gene ID:

  27130

• Accession Number:

  Q9Y283

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from part region of human INVS protein

• Clonality:

  Polyclonal

• Tag:

  INVS

• Applications:

  WB, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  117kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  The antibody detects endogenous levels of INVS protein

• Observed Molecular Weight:

  117

• Formulation:

  Liquid solution

• Buffer pH:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names:

  Inversin; Inversion of embryo turning homolog; Nephrocystin-2

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/Q9Y283

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG