IBTK Polyclonal Antibody

• Background :

  IBTK (Inhibitor Of Bruton Tyrosine Kinase) is a Protein Coding gene. Diseases associated with IBTK include Agammaglobulinemia. Among its related pathways are B cell receptor signaling pathway (KEGG) . Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by IBTK binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. IBTK has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• Description :

  Rabbit Anti-IBTK Polyclonal Antibody

• Product Name Alternative :

  Inhibitor of Bruton tyrosine kinase; IBtk

• Gene ID :

  25998

• Accession Number :

  Q9P2D0

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthesized peptide derived from part region of human IBTK protein at amino acid sequence of 410-490

• Clonality :

  Polyclonal

• Tag :

  IBTK

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  148kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of IBTK protein

• Observed Molecular Weight :

  148

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names :

  Inhibitor of Bruton tyrosine kinase; IBtk

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q9P2D0

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG