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Thianthrene (Standard)

CAT: 0804-HY-W014120R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W014120R-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thianthrene (Standard) is the analytical standard of Thianthrene. This product is intended for research and analytical applications. Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) . Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC50 = 23 μM) . Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo[1][2].
CAS Number
92-85-3
UNSPSC
12352005
Target
Biochemical Assay Reagents; Parasite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thianthrene-standard.html
Smiles
C12=CC=CC=C1SC3=C(C=CC=C3)S2
Molecular Formula
C12H8S2
Molecular Weight
216.32
References & Citations
[1]Mitchell SC, et al. Fate of thianthrene in biological systems. Xenobiotica. 2017 Aug;47 (8) :731-740. |[2]Jaspreet Kaur, et al., (2021), Thianthrene is a novel inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) Journal of Molecular Biochemistry
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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