Haptoglobin Polyclonal Antibody

• Background:

  HP encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in HP and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. HP has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to HP on chromosome 16. Multiple transcript variants encoding different isoforms have been found for HP.

• Description:

  Rabbit Anti-Haptoglobin Polyclonal Antibody

• Product Name Alternative:

  Haptoglobin; Zonulin; Haptoglobin alpha chain; Haptoglobin beta chain

• Gene ID:

  3240

• Accession Number:

  P00738

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Synthesized peptide derived from part region of human Haptoglobin protein at amino acid sequence of 300-360

• Clonality:

  Polyclonal

• Tag:

  Haptoglobin

• Applications:

  IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  The antibody detects endogenous levels of Haptoglobin

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200

• Other Product Names:

  Haptoglobin; Zonulin; Haptoglobin alpha chain; Haptoglobin beta chain

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P00738

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG