Diprovocim-X

CAT: 0804-HY-150501-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-150501-01Size:1 mg

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Description

Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive immune response[1].

CAS Number

3005274-77-8

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/diprovocim-x.html

Purity

98.64

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(OCCCCCCCCCCCCNC([C@@H]1CN(C(C2=CC=C(C(N3C[C@@H](C(N[C@@H]4[C@@H](C5=CC=CC=C5)C4)=O)[C@H](C(N[C@@H]6[C@@H](C7=CC=CC=C7)C6)=O)C3)=O)C=C2)=O)C[C@H]1C(N[C@@H]8[C@@H](C9=CC=CC=C9)C8)=O)=O)CNC(OC(C)(C)C)=O

Molecular Formula

C66H83N7O10

Molecular Weight

1134.41

References & Citations

[1]Yang MH, et al. Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. J Med Chem. 2022 Jun 29.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR1; TLR2

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