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DRA Polyclonal Antibody

CAT: 0749-ABP58418-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58418-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Description
Rabbit Anti-DRA Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
HLA class II histocompatibility antigen; DR alpha chain; MHC class II antigen DRA
Gene ID
3122
Accession Number
P01903
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human DRA protein at amino acid sequence of 100-180
Clonality
Polyclonal
Tag
DRA
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
27kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of DRA protein
Observed Molecular Weight
27
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
HLA class II histocompatibility antigen; DR alpha chain; MHC class II antigen DRA
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P01903
Isotype
Rabbit IgG

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