CRADD Polyclonal Antibody

• Background:

  CRADD encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation inCRADD was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.

• Description:

  Rabbit Anti-CRADD Polyclonal Antibody

• Product Name Alternative:

  Death domain-containing protein CRADD; Caspase and RIP adapter with death domain; RIP-associated protein with a death domain

• Gene ID:

  8738

• Accession Number:

  P78560

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from part region of human CRADD protein at amino acid sequence of 30-110

• Clonality:

  Polyclonal

• Tag:

  CRADD

• Applications:

  WB, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  21kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  The antibody detects endogenous levels of CRADD protein

• Observed Molecular Weight:

  21

• Formulation:

  Liquid solution

• Buffer pH:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names:

  Death domain-containing protein CRADD; Caspase and RIP adapter with death domain; RIP-associated protein with a death domain

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P78560

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG