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TCID

CAT: 0804-HY-18638-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18638-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].
CAS Number
30675-13-9
Product Name Alternative
4,5,6,7-Tetrachloroindan-1,3-dione
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tcid.html
Purity
99.78
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O
Molecular Formula
C9H2Cl4O2
Molecular Weight
283.92
Precautions
H302, H312, H332
References & Citations
[1]Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cellline. Chem Biol. 2003 Sep;10 (9) :837-46.|[2]de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013;8 (3) :e58863.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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