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CD2AP Polyclonal Antibody

CAT: 0749-ABP58057-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58057-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD2AP (CD2 Associated Protein) encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of CD2AP is implicated in susceptibility to glomerular disease. CD2AP is a Protein Coding gene. Diseases associated with CD2AP include Glomerulosclerosis, Focal Segmental, 3 and Sporadic Idiopathic Steroid-Resistant Nephrotic Syndrome With Focal Segmental Hyalinosis.
Description
Rabbit Anti-CD2AP Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains
Gene ID
23607
Accession Number
Q9Y5K6
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human CD2AP protein at amino acid sequence of 320-400
Clonality
Polyclonal
Tag
CD2AP
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
70kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of CD2AP protein
Observed Molecular Weight
70
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9Y5K6
Isotype
Rabbit IgG

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