Products for Research Use Only

CAD12 Polyclonal Antibody

CAT: 0749-ABP57959-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57959-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDH12 (Cadherin 12) encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of CDH12 results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Description
Rabbit Anti-CAD12 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Cadherin-12; Brain cadherin; BR-cadherin; Neural type cadherin 2; N-cadherin 2
Gene ID
1010
Accession Number
P55289
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human CAD12 protein at amino acid sequence of 500-580
Clonality
Polyclonal
Tag
CAD12
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
87kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of CAD12 protein
Observed Molecular Weight
87
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Cadherin-12; Brain cadherin; BR-cadherin; Neural type cadherin 2; N-cadherin 2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P55289
Isotype
Rabbit IgG