AT2B2 Polyclonal Antibody

• Background :

  The protein encoded by ATP2B2 (ATPase Plasma Membrane Ca2+ Transporting 2) belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B2 encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.

• Description :

  Rabbit Anti-AT2B2 Polyclonal Antibody

• Product Name Alternative :

  Plasma membrane calcium-transporting ATPase 2; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2

• Gene ID :

  491

• Accession Number :

  Q01814

• Reactivity :

  Human, Rat

• Immunogen :

  Synthesized peptide derived from part region of human AT2B2 protein at amino acid sequence of 250-330

• Clonality :

  Polyclonal

• Tag :

  AT2B2

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  136kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of AT2B2 protein

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names :

  Plasma membrane calcium-transporting ATPase 2; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q01814

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG