ARRS Polyclonal Antibody

• Background :

  SAG (S-Antigen Visual Arrestin) is a Protein Coding gene. Diseases associated with SAG include Oguchi Disease-1 and Retinitis Pigmentosa 47. Among its related pathways are Phototransduction and Visual Cycle in Retinal Rods. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in SAG have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

• Description :

  Rabbit Anti-ARRS Polyclonal Antibody

• Product Name Alternative :

  S-arrestin; 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin

• Gene ID :

  6295

• Accession Number :

  P10523

• Reactivity :

  Human, Rat, Mouse

• Immunogen :

  Synthesized peptide derived from part region of human ARRS protein at amino acid sequence of 210-290

• Clonality :

  Polyclonal

• Tag :

  ARRS

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  44kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of ARRS protein

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names :

  S-arrestin; 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/P10523

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG