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APBB1 Polyclonal Antibody

CAT: 0749-ABP57787-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57787-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APBB1 (Amyloid Beta Precursor Protein Binding Family B Member 1) is a Protein Coding gene. Diseases associated with APBB1 include Alzheimer Disease and Second-Degree Atrioventricular Block. Among its related pathways are DNA Double Strand Break Response and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The protein encoded by APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for APBB1.
Description
Rabbit Anti-APBB1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65
Gene ID
322
Accession Number
O00213
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human APBB1 protein at amino acid sequence of 400-480
Clonality
Polyclonal
Tag
APBB1
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
78kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of APBB1 protein
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O00213
Isotype
Rabbit IgG

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