APBB1 Polyclonal Antibody

• Background:

  APBB1 (Amyloid Beta Precursor Protein Binding Family B Member 1) is a Protein Coding gene. Diseases associated with APBB1 include Alzheimer Disease and Second-Degree Atrioventricular Block. Among its related pathways are DNA Double Strand Break Response and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The protein encoded by APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for APBB1.

• Description:

  Rabbit Anti-APBB1 Polyclonal Antibody

• Product Name Alternative:

  Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65

• Gene ID:

  322

• Accession Number:

  O00213

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from part region of human APBB1 protein at amino acid sequence of 400-480

• Clonality:

  Polyclonal

• Tag:

  APBB1

• Applications:

  WB, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  78kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  The antibody detects endogenous levels of APBB1 protein

• Formulation:

  Liquid solution

• Buffer pH:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names:

  Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/O00213

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG