MI-3

MI-3

• CAS Number: 1271738-59-0
• UNSPSC Description: MI-3 (Menin-MLL inhibitor 3) is a potent and high affinity menin-MLL inhibitor with an IC50 of 648 nM and a Kd of 201 nM[1].
• Target Antigen: Apoptosis; Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/MI-3.html
• Solubility: DMSO : 8.33 mg/mL (ultrasonic)
• Smiles: CC(C)C1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
• Molecular Weight: 375.55
• References & Citations: [1]Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nature Chemical Biology (2012), 8(3), 277-284.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported