ACO2 Polyclonal Antibody

• Background :

  ACO2 (Aconitase 2) is a Protein Coding gene. Diseases associated with ACO2 include Infantile Cerebellar-Retinal Degeneration and Optic Atrophy 9. Among its related pathways are Metabolism and Citrate cycle (TCA cycle) . The protein encoded by ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification.

• Description :

  Rabbit Anti-ACO2 Polyclonal Antibody

• Product Name Alternative :

  Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase

• Gene ID :

  50

• Accession Number :

  Q99798

• Reactivity :

  Human, Mouse, Rat, Canine

• Immunogen :

  Synthesized peptide derived from part region of human ACO2 protein at amino acid sequence of 421-470

• Clonality :

  Polyclonal

• Tag :

  ACO2

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  90kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of ACO2

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:5000.Not yet tested in other applications.

• Other Product Names :

  Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q99798

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG