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WISP-3 Polyclonal Antibody

CAT: 0749-ABP57595-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP57595-01Size:30 µL
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Background
WISP3 (WNT1 inducible signaling pathway protein 3) encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of WISP3 are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for WISP3.
Description
Rabbit Anti-WISP-3 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
WNT1-inducible-signaling pathway protein 3; WISP-3; CCN family member 6
Gene ID
8838
Accession Number
O95389
Reactivity
Human, Mouse
Immunogen
Synthetic peptide from human protein at AA range: 1-50
Clonality
Polyclonal
Tag
WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6)
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
55kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous WISP-3.
Observed Molecular Weight
55
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:10000-20000
Other Product Names
WNT1-inducible-signaling pathway protein 3; WISP-3; CCN family member 6
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O95389
Isotype
Rabbit IgG

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