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Collagen IV Polyclonal Antibody

CAT: 0749-ABP57493-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57493-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
COL4A1 (collagen type IV alpha 1 chain) encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. COL4A1 shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in COL4A1 cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
Description
Rabbit Anti-Collagen IV Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Collagen, type IV, alpha 1
Gene ID
1282
Accession Number
P02462
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from Collagen IV at AA range: 1428-1443
Clonality
Polyclonal
Tag
Collagen IV
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
130kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Collagen IV Polyclonal Antibody detects endogenous levels of Collagen IV.
Observed Molecular Weight
130
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:10000-20000
Other Product Names
Collagen, type IV, alpha 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P02462
Isotype
Rabbit IgG

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