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MUM1 Polyclonal Antibody

CAT: 0749-ABP57478-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57478-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA double-strand breaks (DSBs) are potentially hazardous lesions that can be induced by ionizing radiation (IR), radiomimetic chemicals, or DNA replication inhibitors. Melanoma associated antigen (mutated) 1 (MUM1, EXPAND1) is a PWWP-domain containing chromatin binding protein involved in maintaining chromatin architecture of interphase chromosomes. In response to DNA damage, EXPAND1/MUM1 accumulates at sites of DNA double strand breaks through direct interaction with DNA repair factor 53BP1. Accumulation of EXPAND1/MUM1 at damaged DNA sites is thought to modify the structure of the chromatin and allow access to other DNA repair factors. 53BP1 activates the checkpoint kinase ATM and promotes DNA double strand break repair via nonhomologous end joining (NHEJ) repair pathway.
Description
Rabbit Anti-MUM1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Melanoma associated antigen (mutated) 1
Gene ID
84939
Accession Number
Q2TAK8
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from MUM1 at AA range: 661-710
Clonality
Polyclonal
Tag
MUM1
Applications
WB, ELISA, IHC
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
78kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MUM1 Polyclonal Antibody detects endogenous levels of MUM1.
Observed Molecular Weight
78
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Other Product Names
Melanoma associated antigen (mutated) 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q2TAK8
Isotype
Rabbit IgG

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