CD35 Polyclonal Antibody

CAT: 0749-ABP57474-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP57474-01Size:30 µL
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Background
CR1 (complement C3b/C4b receptor 1 (Knops blood group) ) is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. CR1 encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in CR1 have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
Description
Rabbit Anti-CD35 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Complement component (3b/4b) receptor 1/2 (Knops blood group)
Gene ID
1378
Accession Number
P17927/Q2VPA4
Reactivity
Human
Immunogen
Synthesized peptide derived from CD35 at AA range: Internal
Clonality
Polyclonal
Tag
CD35
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
220kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CD35 Polyclonal Antibody detects endogenous levels of CD35.
Observed Molecular Weight
220
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:10000-20000
Other Product Names
Complement component (3b/4b) receptor 1/2 (Knops blood group)
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P17927/Q2VPA4
Isotype
Rabbit IgG

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