Centriolin Polyclonal Antibody

• Background:

  Cytokinesis occurs during the late stages of mitosis and describes the process by which the cytoplasm of one cell is divided to create two subsequent daughter cells. Centriolin, also known as CEP110, is a coiled-coil centrosomal protein that is required for centrosome maturation and correct centrosome function. During abscission, the last step in cytokinesis, Centriolin both coordinates and grounds vesicle-fusion and vesicle-exocyst complexes to the midbody of the daughter cells. Acting as an anchor for the protein complexes needed to complete separation of the two cells, Centriolin initiates and controls vesicle-mediated cell cleavage. Through its ability to signal initiation of the last step of vertebrate cytokinesis, Centriolin regulates cell proliferation and contributes to proper entry into the S phase of mitosis.

• Description:

  Rabbit Anti-Centriolin Polyclonal Antibody

• Product Name Alternative:

  CCP110; CEP110; CP110; KIAA0419; Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110

• Gene ID:

  9738

• Accession Number:

  O43303

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from the C-terminal region of human Centriolin

• Clonality:

  Polyclonal

• Tag:

  Centriolar coiled-coil protein of 110 kDa

• Applications:

  IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  Centriolin Polyclonal Antibody detects endogenous levels of Centriolin protein.

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200

• Other Product Names:

  CCP110; CEP110; CP110; KIAA0419; Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/O43303

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG