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Troponin I-C Polyclonal Antibody

CAT: 0749-ABP56408-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56408-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: tnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. NNI3 (troponin I3, cardiac type) encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in TNNI3 cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) .
Description
Rabbit Anti-Troponin I-C Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I
Gene ID
7137
Accession Number
P19429
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Troponin I-C around the non-phosphorylation site of T142
Clonality
Polyclonal
Tag
Troponin I cardiac muscle
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
28kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Troponin I-C Polyclonal Antibody detects endogenous levels of Troponin I-C protein.
Observed Molecular Weight
28
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P19429
Isotype
Rabbit IgG

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