PGI2 synthase Polyclonal Antibody

• Background :

  PTGIS (prostaglandin I2 (prostacyclin) synthase) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

• Description :

  Rabbit Anti-PGI2 synthase Polyclonal Antibody

• Product Name Alternative :

  PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

• Gene ID :

  5740

• Accession Number :

  Q16647

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthesized peptide derived from the C-terminal region of human PGI2 synthase

• Clonality :

  Polyclonal

• Tag :

  Prostacyclin synthase

• Applications :

  WB, ELISA, IHC

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  57kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein.

• Observed Molecular Weight :

  57

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000

• Other Product Names :

  PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q16647

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG