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PAF-R Polyclonal Antibody

CAT: 0749-ABP55881-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55881-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTAFR (platelet activating factor receptor) encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Description
Rabbit Anti-PAF-R Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
Gene ID
5724
Accession Number
P25105
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human PAF-R at AA range: 170-250
Clonality
Polyclonal
Tag
Platelet-activating factor receptor
Applications
IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications
Other Product Names
PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P25105
Isotype
Rabbit IgG

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