SphK2 Polyclonal Antibody

• Background:

  SPHK2 (sphingosine kinase 2) encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for SPHK2.

• Description:

  Rabbit Anti-SphK2 Polyclonal Antibody

• Product Name Alternative:

  SPHK2; Sphingosine kinase 2; SK 2; SPK 2

• Gene ID:

  56848

• Accession Number:

  Q9NRA0

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human SphK2 around the non-phosphorylation site of T614

• Clonality:

  Polyclonal

• Tag:

  Sphingosine kinase 2

• Applications:

  WB, IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  70kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  SphK2 Polyclonal Antibody detects endogenous levels of SphK2 protein.

• Observed Molecular Weight:

  70

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200

• Other Product Names:

  SPHK2; Sphingosine kinase 2; SK 2; SPK 2

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/Q9NRA0

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG