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Arkadia Polyclonal Antibody

CAT: 0749-ABP55676-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55676-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.
Description
Rabbit Anti-Arkadia Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
Gene ID
54778
Accession Number
Q6ZNA4
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human Arkadia at AA range: 870-950
Clonality
Polyclonal
Tag
E3 ubiquitin-protein ligase Arkadia
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
110kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q6ZNA4
Isotype
Rabbit IgG

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