PLB Polyclonal Antibody

CAT: 0749-ABP55624-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP55624-01Size:30 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by PLN (phospholamban) is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca (2+) -ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Description
Rabbit Anti-PLB Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
PLN; PLB; Cardiac phospholamban; PLB
Gene ID
5350
Accession Number
P26678
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human PLB around the non-phosphorylation site of S16/T17
Clonality
Polyclonal
Tag
Cardiac phospholamban
Applications
WB, IHC
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PLB Polyclonal Antibody detects endogenous levels of PLB protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300
Other Product Names
PLN; PLB; Cardiac phospholamban; PLB
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P26678
Isotype
Rabbit IgG

Related Products

CatalogName
ABP55623-01PLB (phospho Ser16/T17) Polyclonal Antibody
ANT-13798-100ugPLB1 Polyclonal Antibody
ANT-13798-50ugPLB1 Polyclonal Antibody
ANT-15047-50ugWAS Polyclonal Antibody
ANT-15047-100ugWAS Polyclonal Antibody
ANT-13843-100ugPolyclonal Antibody
ANT-13843-50ugPolyclonal Antibody
ABP51603-01IKKBeta Polyclonal AntibodyIKKβ Polyclonal Antibody
ABP50715-01AR-Beta2 Polyclonal AntibodyAR-β2 Polyclonal Antibody
ANT-14078-50ugRASA1 Polyclonal Antibody

Alternative Products

CatalogName
RD81942A-01Polyclonal AntibodyPC1 Polyclonal Antibody
APR00447GPolyclonal BRD2 polyclonal antibody
APR00458GPolyclonal KDM4D polyclonal antibody
APR00372GPolyclonal ETO polyclonal antibody
APR12526GPolyclonal MeCP2 polyclonal antibody
APR15992GPolyclonal FKBP51 polyclonal antibody
APR00452GPolyclonal BCL7C polyclonal antibody
APR11187GPolyclonal Rtf1 polyclonal antibody
APR12517GPolyclonal Med26 polyclonal antibody
APG01659GPolyclonal AKR1B10 Polyclonal Antibody

Popular Products