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HMP19 Polyclonal Antibody

CAT: 0749-ABP55550-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55550-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility. The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas. PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility. ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation.
Description
Rabbit Anti-HMP19 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
NSG2; Neuron-specific protein family member 2; Protein p19; Hmp19
Gene ID
51617
Accession Number
Q9Y328
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human HMP19 at AA range: 10-90
Clonality
Polyclonal
Tag
Neuron-specific protein family member 2
Applications
IHC, IF, WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
19kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
HMP19 Polyclonal Antibody detects endogenous levels of HMP19 protein.
Observed Molecular Weight
19
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
NSG2; Neuron-specific protein family member 2; Protein p19; Hmp19
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9Y328
Isotype
Rabbit IgG

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