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LIMK-1 Polyclonal Antibody

CAT: 0749-ABP55115-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55115-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description
Rabbit Anti-LIMK-1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
LIMK1; LIMK; LIM domain kinase 1; LIMK-1
Gene ID
3984
Accession Number
P53667
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human LIMK-1 around the non-phosphorylation site of T508
Clonality
Polyclonal
Tag
LIM domain kinase 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
65kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
LIMK-1 Polyclonal Antibody detects endogenous levels of LIMK-1 protein.
Observed Molecular Weight
65
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
LIMK1; LIMK; LIM domain kinase 1; LIMK-1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P53667
Isotype
Rabbit IgG

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