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5-PAHSA

CAT: 0804-HY-116193-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116193-01Size:5 mg
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Description
5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3].
CAS Number
1481636-41-2
Product Name Alternative
trans-PX-102, (-)-PX-102 (trans isomer); (-)-PX-104, PX-111, ABR-215757-d5-1; ABR 25757-d5-1
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H331-H336-H351-H361-H372-H412
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-pahsa.html
Concentration
10mM
Purity
98.08
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
OC(CCCC(CCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCC)=O)=O
Molecular Formula
C34H66O4
Molecular Weight
538.89
Precautions
P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wang JT, et al. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27 (4) :484-496.|[2]Paluchova V, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69 (3) :300-312. |[3]Wang YM, et al. High Glucose Concentration Impairs 5-PAHSA Activity by Inhibiting AMP-Activated Protein Kinase Activation and Promoting Nuclear Factor-Kappa-B-Mediated Inflammation. Front Pharmacol. 2019 Jan 7;9:1491.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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