Products for Research Use Only

MLH3 Polyclonal Antibody

CAT: 0749-ABP54532-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP54532-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7) . Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Description
Rabbit Anti-MLH3 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3
Gene ID
27030
Accession Number
Q9UHC1
Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of human MLH3 at AA rangle: 490-570
Clonality
Polyclonal
Tag
DNA mismatch repair protein Mlh3
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
164kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MLH3 Polyclonal Antibody detects endogenous levels of MLH3 protein.
Observed Molecular Weight
164
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9UHC1
Isotype
Rabbit IgG

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