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Defensin α1 Polyclonal Antibody

CAT: 0749-ABP53989-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP53989-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Neutrophil defensin 1 encoded by DEFA1, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Description
Rabbit Anti-Defensin α1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
DEFA1; DEF1; DEFA2; MRS; DEFA1B; Neutrophil defensin 1; Defensin; alpha 1; HNP-1; HP-1; HP1
Gene ID
1667
Accession Number
P59665
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Defensin α1
Clonality
Polyclonal
Tag
Neutrophil defensin 1
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
11kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Defensin α1 Polyclonal Antibody detects endogenous levels of Defensin α1 protein.
Observed Molecular Weight
11
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
DEFA1; DEF1; DEFA2; MRS; DEFA1B; Neutrophil defensin 1; Defensin; alpha 1; HNP-1; HP-1; HP1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P59665
Isotype
Rabbit IgG

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