Doublecortin Polyclonal Antibody

CAT: 0749-ABP53978-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP53978-01Size:30 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
DCX encodes a member of the doublecortin family. Neuronal migration protein doublecortin encoded by DCX is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Description
Rabbit Anti-Doublecortin Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X
Gene ID
1641
Accession Number
O43602
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Doublecortin around the non-phosphorylation site of S378
Clonality
Polyclonal
Tag
Neuronal migration protein doublecortin
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
44kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Doublecortin Polyclonal Antibody detects endogenous levels of Doublecortin protein.
Observed Molecular Weight
44
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O43602
Isotype
Rabbit IgG

Related Products

CatalogName
ABP53976-01Doublecortin (phospho Ser376) Polyclonal Antibody
KTE100787-01ELISA kit for Rat Neuronal migration protein doublecortin (DCX)
KTE71322-01ELISA kit for Mouse Neuronal migration protein doublecortin (DCX)
KTE62125-01ELISA kit for Human Neuronal migration protein doublecortin (DCX)
KTE62135-01ELISA kit for Human Doublecortin domain-containing protein 5 (DCDC5)
ANT-13843-100ugPolyclonal Antibody
ANT-15047-50ugWAS Polyclonal Antibody
ANT-15047-100ugWAS Polyclonal Antibody
ANT-13843-50ugPolyclonal Antibody
ABP51603-01IKKBeta Polyclonal AntibodyIKKβ Polyclonal Antibody

Alternative Products

CatalogName
MBS8592148-01Doublecortin Polyclonal Antibody
BS77274Doublecortin polyclonal antibody
35-1798-50Polyclonal Antibody to Doublecortin
AMM05842GPolyclonal Doublecortin Antibody

Popular Products