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PSGL-1 Polyclonal Antibody

CAT: 0749-ABP53303-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP53303-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, selectin P ligand plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Description
Rabbit Anti-PSGL-1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
Gene ID
6404
Accession Number
Q14242
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human PSGL-1
Clonality
Polyclonal
Tag
P-selectin glycoprotein ligand 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
45kD,110kD (glycosylated)
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PSGL-1 Polyclonal Antibody detects endogenous levels of PSGL-1 protein.
Observed Molecular Weight
45
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q14242
Isotype
Rabbit IgG

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